Nota de FísicaPublicado
Calculus of the Site Specific Oxygen Binding Constants of Hemoglobin
S. G. Jacchieri; Ricardo Ferreira
1985
Dados da publicação
- Autores
- S. G. Jacchieri; Ricardo Ferreira
- Tipo
- Nota de Física
- Status
- Publicado
- Data de publicação
- 1985
- Descrição
- The site specifics binding constants of the hemoglobin- dioxygen equilibria were calculated with the aid of two approximations based in distinct, though related, features of the hemoglobin's problem. The first approximation (AI) is based on the well stablished proeminency of the role played by the <math>\alpha_I \beta_ {II}\,\!</math> interfaces (Perutz, 1970) in the mechanism of cooperativity. The second approximation (AII) is based in the selective character of the binding of some organic phosphates to the <math>\beta \beta \,\!</math> inter face (Benesch, Benesch and Enoki, 1968; Arnone and Perutz, 1974). A comparison between the two approximations showed that, except for the constraining of the <math>\beta \,\!</math> sites binding constants in AI, the two approximations give similar results. Also, thepresent calculations agree with known facts, such as the preferential binding of the <math>\alpha \,\!</math> sites (Lindstron and Ho, 1972;Johnson and Ho, 1974; Asakura and Pui Wah, 1978) and the qua¬ternary enhancement (Mills ans Ackers, 1979).
- Ano
- 1985
- Número
- CBPF-NF-036/85
- Vínculo com tese
- Não
- Vínculo com bolsa
- Não